The dose and method of application are determined by the severity of circulatory disorders, as well as based on the individual tolerance of the drug. The dosage is set by the doctor in accordance with the individual characteristics of the patient. In patients with renal failure (creatinine clearance less than 30 ml/min), it is necessary to reduce the dosage by 30-50%, which depends on the individual tolerance of the drug to the patient.
In elderly patients, a dose reduction (increased bioavailability and decreased excretion rate) may be required.
There are contraindications, consult with a specialist before use